0
Skip to Content
Gan Laboratory
Research
Team
Current Members
Alumni
Publications
News
Life in the Lab
Core Values
Gan Laboratory
Research
Team
Current Members
Alumni
Publications
News
Life in the Lab
Core Values
Research
Folder: Team
Back
Current Members
Alumni
Publications
News
Life in the Lab
Core Values
Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model (Copy)
NIAN Claire Hu 4/25/24 NIAN Claire Hu 4/25/24

Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model (Copy)

Neuron, 2024

Read More
HSCDM ScienceSites 9/20/23 HSCDM ScienceSites 9/20/23

A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states

Nature Neuroscience, 2022

Read More
HSCDM ScienceSites 9/20/23 HSCDM ScienceSites 9/20/23

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration

Cell, 2022

Read More
HSCDM ScienceSites 9/20/23 HSCDM ScienceSites 9/20/23

Pathogenic tau impairs axon initial segment plasticity and excitability homeostasis

Neuron, 2019

Read More
HSCDM ScienceSites 9/20/23 HSCDM ScienceSites 9/20/23

Scalable production of iPSC-derived human neurons to identify tau-lowering compounds by high-content screening

Stem Cell Reports, 2017

Read More
HSCDM ScienceSites 9/20/23 HSCDM ScienceSites 9/20/23

Imbalance between GABAergic and glutamatergic transmission impairs adult neurogenesis in an animal model of Alzheimer's Disease

Cell Stem Cell, 2009

Read More
DTPND ScienceSites 9/20/23 DTPND ScienceSites 9/20/23

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration

Cell, 2022

Read More
DTPND ScienceSites 9/20/23 DTPND ScienceSites 9/20/23

Acetylated tau obstructs KIBRA-mediated signaling in synaptic plasticity and promotes tauopathy-related memory loss

Neuron, 2016

Read More
DTPND ScienceSites 9/20/23 DTPND ScienceSites 9/20/23

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

Nature Medicine, 2015

Read More
DTPND ScienceSites 9/20/23 DTPND ScienceSites 9/20/23

Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation

Acta Neuropathologica, 2013

Read More
DTPND ScienceSites 9/20/23 DTPND ScienceSites 9/20/23

Acetylation of tau inhibits its degradation and contributes to tauopathy

Neuron, 2010

Read More
NIAN ScienceSites 9/20/23 NIAN ScienceSites 9/20/23

Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience

Nature Neuroscience, 2023

Read More
NIAN ScienceSites 9/20/23 NIAN ScienceSites 9/20/23

Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

Nature Communications, 2022

Read More
NIAN ScienceSites 9/20/23 NIAN ScienceSites 9/20/23

AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation

Science, 2021

Read More
NIAN ScienceSites 9/20/23 NIAN ScienceSites 9/20/23

Microglial microRNAs mediate sex-specific responses to tau pathology

Nature Neuroscience, 2020

Read More
NIAN ScienceSites 9/20/23 NIAN ScienceSites 9/20/23

Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia

PNAS, 2017

Read More

Contact

Gan Laboratory
Weill Cornell Medicine

Helen & Robert Appel Alzheimer’s Disease Research Institute
413 E. 69th St.
Belfer Research Building 9th Floor
New York, NY 10021
Email: Ana Carney Appel Administrative; Billy Coronas Laboratory Manager

Connect with Gan Lab

 
© Gan Lab | Designed and Developed by ScienceSites: Websites for Scientists